Endocrine Abstracts

Background: Recent studies have reported a correlation between the increase in incidence of Type 1 Diabetes (T1DM) in children and young people (CYP) and SARS-COVID19 Infection.Aims and objectives: To study if there is an increase in TIDM incidence in CYP (aged 0-18yrs) post-covid19 (April 2020- March 2021) in East of England (EOE) region compared to previous years (April 2018- March 2020). To identify a correlation between T1DM incidence and the UK COVI...

Introduction: Graves’ disease is the commonest cause of thyrotoxicosis; and is usually responsive to radio-iodine therapy. In Nigeria, radio-iodine therapy is becoming a common and cost effective option for treatment of thyrotoxicosis; with the less likelihood of most of the complications associated with thyroidectomy.Case presentation: A 49-year-old Nigerian lady, presented to the endocrinology clinic, at LAUTECH Teaching Hospital, Ogbomoso, 8 year...

Background: Hypercalcaemia is a commonly encountered electrolyte abnormality within the acute medical take; identification of the underlying aetiology can guide optimised care.Case : A 23 year old male patient with a background of insulin dependent diabetes, diabetic nephropathy (chronic kidney disease stage 1) was admitted feeling acutely unwell. Clinical and bed side investigations identified he was in severe diabetes ketoacidosis. His condition prompt...

Pituitary adenomas are frequent intracranial tumors that often associate with the hypersecretion of pituitary hormones or may be non-secreting (nonfunctioning pituitary adenomas, NFPA). Tumors resembling human NFPAs develop with complete penetrance in rats affected by the multiple endocrine neoplasia syndrome, MENX. This syndrome is caused by a germline loss of function mutation in p27Kip1. Gene expression array analysis performed in our group identified a considera...

Background and aims: Immediate release somatostatin analogues (SAs) have routinely been administered to test tolerability prior to commencing long-acting SAs, though there is limited evidence to support this process. We aim to examine this practice at our centre.Methods: Patients who received SA therapy for a neuro endocrine tumours (NET) between December 2012 and December 2014 were identified. Records were used to identify; start date, duration of test-...

We report a case of acute adrenal crisis in a patient with the antiphospholipid syndrome in a man who was on a therapeutic dose of warfarin. A 64-year-old man presented with vomiting and abdominal discomfort. Temperature was 37.8 °C, pulse 85/min and BP 100/63 mmHg. On examination, there was generalized hyperpigmentation. He had a history of deep venous thrombosis of the lower limbs on two occasions and was on warfarin. He previously diagnosed primary antiphospho...

A 54 year-old businesswoman who has been diabetic for 6 years and had a history of PUD. She was referred following complaints of increasing hyperpigmentation of her palms, feet and old scars. She also had a boil on her back, significant weight loss, poor appetite and a slight non-productive cough.She was transfused with two pints of blood a month earlier at a private hospital when her PCV was found low. She is not hypertensive. Her drug history included ...

Introduction: In addition to safety and efficacy, patient satisfaction with treatment is potentially a key factor in maintaining therapy adherence. Testosterone replacement therapy (TRT) is provided using a variety of products with different features and routes of administration. These differing product characteristics may impact on patient satisfaction and adherence with a concomitant impact on well-being and health-related quality of life. The aim of this study was to explor...

Introduction: This is an audit on the outcome of children and young people (CYP) with Type 1 Diabetes with high HbA1c who were offered extra appointments with a paediatric diabetes specialist nurse (PDSN) over a three-year period at Harrogate District Hospital.Patient population: 26 CYP with Type 1 Diabetes with HbA1C more than 75mmol/mol, were offered extra diabetes clinic appointments with a PDSN.Audit Methodology: A retrospectiv...

Background: The function of the thyroid gland effects on obesity and comorbidities. It has been proven for bariatric surgery to be the most effective in obesity treatment.Aim: To evaluate the dynamics of body weight, thyroid status, leptin and insulin resistance in obese patients after bariatric surgery.Materials and methods: 78 obese patients were observed after bariatric surgery (sleeve gastrectomy – 46, gastric bypass &#82...